Medical management of Ricin poisoning

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Ricin poisoning and forensic toxicology.

Ricin is one of the most fascinating poisons due to its high toxicity: as little as 500 microg can kill an adult. It gained fame by its use in the so-called 'umbrella murder' to kill the Bulgarian dissident Georgi Markov in 1978. Ricin also became known as a potential bio-terror agent to which people could be exposed through the air, food, or water. The origin, biochemistry, toxicity, and analy...

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Passive and Active Vaccination Strategies to Prevent Ricin Poisoning

Ricin toxin (RT) is derived from castor beans, produced by the plant Ricinus communis. RT and its toxic A chain (RTA) have been used therapeutically to arm ligands that target disease-causing cells. In most cases these ligands are cell-binding monoclonal antibodies (MAbs). These ligand-toxin conjugates or immunotoxins (ITs) have shown success in clinical trials [1]. Ricin is also of concern in ...

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ژورنال

عنوان ژورنال: Journal of Medical and Allied Sciences

سال: 2017

ISSN: 2231-1696

DOI: 10.5455/jmas.259532